Can You Take Vitamin E and Vitamin K1 Together?
Usually, at standard doses. Long-term high-dose vitamin E may interfere with vitamin K-dependent clotting.
The short answer
Vitamin E and vitamin K1 are usually compatible at ordinary doses, but long-term high-dose vitamin E may affect vitamin K-related clotting.
Why it happens
In a 12-week human trial, 1,000 IU per day of vitamin E increased PIVKA-II, a marker of poorer vitamin K status, although the clinical significance remains uncertain.
What to do
Spacing them by a few hours does not address this issue. Avoid unsupervised long-term high-dose vitamin E and keep vitamin K intake consistent.
When this advice applies
Ask a clinician first if you take warfarin or other anticoagulant or antiplatelet medicines, have a bleeding risk, or have low vitamin K status. The vitamin E dose that causes clinically important effects is not firmly established.
References
- Vitamin E — Health Professional Fact SheetNIH Office of Dietary Supplements · 2026
- Vitamin E supplementation and vitamin K status in adults with normal coagulation statusAmerican Journal of Clinical Nutrition / PubMed · 2004
Updated July 31, 2026 · How to use this guidance