Can You Take Vitamin A and Vitamin D2 Together?

Dose or timing may matter

The short answer

High-dose vitamin A antagonizes vitamin D function at the VDR receptor level. Vitamin D2 (ergocalciferol) has lower receptor affinity than D3, making it more susceptible to vitamin A antagonism.

How to arrange timing

Avoid mega-dosing vitamin A if taking vitamin D2. Consider using vitamin D3 instead for better receptor binding.

Reference

Reference noted for this combination: Johansson S, Melhus H. Vitamin A antagonizes calcium response to vitamin D in man. J Bone Miner Res. 2001;16(10):1899-1905

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.