Can You Take Valerian Root and Wild Lettuce Together?

Use extra care with this pair

The short answer

Wild lettuce has mild sedative and analgesic properties; combining with valerian's GABAergic effects may cause excessive sedation.

How to arrange timing

Consider using one at a time for relaxation.

Reference

Reference noted for this combination: Wesolowska et al., 2006, J Ethnopharmacol

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.