Can You Take SAMe and Vitamin B12 Together?

Dose or timing may matter

The short answer

SAMe (S-adenosylmethionine) depends on vitamin B12 for regeneration via the methionine synthase pathway. SAMe supplementation without adequate B12 may deplete methyl group availability and lead to functional B12 depletion.

How to arrange timing

Ensure adequate B12 and folate status when supplementing SAMe to maintain the methylation cycle.

Reference

Reference noted for this combination: Bottiglieri T. S-Adenosyl-L-methionine (SAMe): from the bench to the bedside. Am J Clin Nutr. 2002;76(5):1151S-1157S

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.