Can You Take Menaquinone-4 (MK-4) and Vitamin E Together?

Dose or timing may matter

The short answer

High-dose vitamin E (≥400 IU) antagonizes vitamin K function by inhibiting vitamin K-dependent carboxylase and vitamin K epoxide reductase. MK-4 (menaquinone-4) is a short-chain vitamin K2 form particularly affected due to its rapid turnover.

How to arrange timing

Avoid high-dose vitamin E (>400 IU/day) if supplementing MK-4 for bone or cardiovascular health.

Reference

Reference noted for this combination: Booth SL et al. Am J Clin Nutr. 2004;80(1):143-148

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.