Can You Take Melatonin and Yohimbine Together?

Dose or timing may matter

The short answer

Yohimbine's alpha-2 adrenergic antagonism increases norepinephrine, which may counteract melatonin's calming effects.

How to arrange timing

Separate by at least 4-5 hours; avoid yohimbine in the evening.

Reference

Reference noted for this combination: Tam et al., 2001, Pharmacol Biochem Behav

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.