Can You Take Melatonin and Vitamin B12 Together?

Dose or timing may matter

The short answer

Vitamin B12 may suppress melatonin secretion by influencing methylation pathways. Some individuals report disrupted sleep when taking B12 at night.

How to arrange timing

Take vitamin B12 in the morning and melatonin before bed.

Reference

Reference noted for this combination: Examine.com

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.