Can You Take Magnesium and Vitamin B6 Together?
Yes. A small human study suggests vitamin B6 may influence magnesium handling, and there is no absorption-based reason to separate them.
The short answer
Magnesium and vitamin B6 can be taken together. Evidence for how B6 affects magnesium levels is limited and includes a very small study using high-dose B6.
Why it happens
In a four-week study of only nine women, high-dose vitamin B6 increased plasma and red-blood-cell magnesium. This supports a relationship, but the evidence base is small.
What to do
They can be taken together with no fixed gap. Follow label doses and do not copy the high vitamin B6 dose used in the study.
When this advice applies
The study used 200 mg/day of vitamin B6, far above normal requirements. Long-term high-dose B6 can cause peripheral neuropathy.
References
- Effect of vitamin B-6 on plasma and red blood cell magnesium levels in premenopausal womenAnnals of Clinical & Laboratory Science · 1981
- Vitamin B6 — Health Professional Fact SheetNIH Office of Dietary Supplements · 2025
Updated July 31, 2026 · How to use this guidance