Can You Take Lysozyme and Probiotics Together?

Dose or timing may matter

The short answer

Lysozyme hydrolyzes peptidoglycan in bacterial cell walls, which is its primary antimicrobial mechanism. Taking lysozyme with probiotics may kill or damage beneficial probiotic bacteria before they can colonize the gut.

How to arrange timing

Separate lysozyme from probiotics by at least 2 hours. Lysozyme can be taken with meals while probiotics are best taken on an empty stomach.

Reference

Reference noted for this combination: Callewaert L, Michiels CW. Lysozymes in the animal kingdom. J Biosci. 2010;35(1):127-160.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.