Can You Take L-Methionine and Vitamin B6 Together?

Dose or timing may matter

The short answer

High-dose methionine increases homocysteine production; vitamin B6 is consumed as a cofactor in the transsulfuration pathway to metabolize homocysteine, potentially depleting B6 stores.

How to arrange timing

Supplement B6, folate, and B12 when taking high-dose methionine to support homocysteine metabolism.

Reference

Reference noted for this combination: Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1(5):228-237

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.