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Can You Take L-Histidine and Zinc Together?
May affect absorption
The short answer
L-Histidine has a high affinity for zinc ions and forms stable histidine-zinc chelates. This can alter the bioavailability of supplemental zinc, either enhancing or interfering with absorption depending on the ratio.
How to arrange timing
Separate L-Histidine and zinc supplements by at least 1 hour to avoid unpredictable absorption changes.
Reference
Reference noted for this combination: Pécoud A, et al. Effect of foodstuffs on the absorption of zinc sulfate. Clin Pharmacol Ther. 1975;17(4):469-474.
Important context
Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.