Can You Take Iron and Vitamin B6 Together?

Dose or timing may matter

The short answer

Excess iron may interfere with vitamin B6 metabolism by catalyzing oxidative degradation of pyridoxal phosphate (PLP), the active form of B6, reducing its availability as a coenzyme.

How to arrange timing

If supplementing high-dose iron, monitor B6 status and supplement if needed.

Reference

Reference noted for this combination: Leklem JE. Vitamin B-6: a status report. J Nutr. 1990;120(Suppl 11):1503-1507

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.