Can You Take Iron and Papain Together?

May affect absorption

The short answer

Papain (a proteolytic enzyme) can cause GI irritation and nausea, and Iron supplements are well-known stomach irritants. Combined use increases GI stress.

How to arrange timing

Separate by at least 2 hours.

Reference

Reference noted for this combination: Muss et al., 2013 — Papain GI effects; NIH ODS — Iron

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.