Can You Take Iron and Nordihydroguaiaretic Acid Together?

May affect absorption

The short answer

Nordihydroguaiaretic Acid (NDGA) is a lignan with catechol groups that chelate iron. NDGA forms stable iron complexes that significantly reduce iron bioavailability.

How to arrange timing

Separate NDGA and iron supplements by at least 2 hours.

Reference

Reference noted for this combination: Floriano-Sanchez E, et al. Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical. Food Chem Toxicol. 2006;44(12):2070-2077.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.