Can You Take Hydroxocobalamin and Methylcobalamin Together?

May affect absorption

The short answer

Hydroxocobalamin and methylcobalamin are both vitamin B12 forms competing for the same intrinsic factor-dependent ileal absorption pathway. High-dose co-supplementation may reduce the effective absorption of each form.

How to arrange timing

Choose one B12 form, or space them at least 2 hours apart.

Reference

Reference noted for this combination: Obeid R et al. Mol Nutr Food Res. 2015;59(7):1364-1372

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.