Can You Take Hops and Melatonin Together?

Use extra care with this pair

The short answer

Hops contain 2-methyl-3-buten-2-ol which enhances GABA activity; combining with melatonin may cause excessive sedation.

How to arrange timing

Reduce doses if combining; avoid driving afterward.

Reference

Reference noted for this combination: Franco et al., 2012, Acta Physiol

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.