Can You Take Grape Seed Extract and Iron Together?

Dose or timing may matter

The short answer

Grape seed extract contains oligomeric proanthocyanidins (OPCs) that chelate iron ions through their catechol/gallol groups, reducing iron bioavailability for hemoglobin synthesis and iron-dependent enzymatic functions.

How to arrange timing

Take grape seed extract and iron supplements at different times to optimize iron absorption.

Reference

Reference noted for this combination: Santos-Buelga C, Scalbert A. Proanthocyanidins and tannin-like compounds. J Sci Food Agric. 2000;80(7):1094-1117

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.