Can You Take Glycerol Powder and Sodium Bicarbonate Together?

Dose or timing may matter

The short answer

Glycerol powder promotes hyperhydration and fluid retention, while sodium bicarbonate provides a large sodium load. Together, they may cause excessive fluid retention, GI distress, and elevated blood pressure.

How to arrange timing

Monitor total fluid and sodium balance when combining. Consider reducing sodium bicarbonate dose if using glycerol for hyperhydration.

Reference

Reference noted for this combination: van Rosendal SP et al. Guidelines for glycerol use in hyperhydration and rehydration associated with exercise. Sports Med. 2010;40(2):113-129

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.