Can You Take Fish Oil (Omega-3) and Phosphatidic Acid Together?

May affect absorption

The short answer

Phosphatidic acid activates the mTOR pathway for muscle protein synthesis, while high-dose fish oil (EPA) has been shown to suppress mTOR signaling. They may partially counteract each other's effects on muscle anabolism.

How to arrange timing

Separate phosphatidic acid from high-dose fish oil by 3–4 hours if using PA specifically for mTOR activation around training.

Reference

Reference noted for this combination: Joy JM et al. Phosphatidic acid enhances mTOR signaling and resistance exercise stimulated hypertrophy. Nutr Metab. 2014;11:29

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.