Can You Take EPA and Pomegranate Seed Oil Together?

Dose or timing may matter

The short answer

Pomegranate Seed Oil is rich in punicic acid (conjugated linolenic acid), which modulates eicosanoid synthesis. EPA also modulates eicosanoid pathways. Their combined effects on prostaglandin balance may partially antagonize each other's anti-inflammatory mechanisms.

How to arrange timing

The interaction between punicic acid and EPA on eicosanoid pathways is complex. Consider taking them at different times if using both for anti-inflammatory purposes.

Reference

Reference noted for this combination: Vroegrijk IO et al., Biochimica et Biophysica Acta, 2011; Punicic acid and eicosanoid metabolism

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.