Can You Take Green Tea Extract (EGCG) and NADH (Reduced NAD+) Together?

Dose or timing may matter

The short answer

EGCG inhibits NADH dehydrogenase (Complex I) in the mitochondrial electron transport chain, potentially reducing the effectiveness of NAD/NADH supplementation for cellular energy production.

How to arrange timing

If supplementing NADH for energy, consider separating it from high-dose EGCG or green tea extract.

Reference

Reference noted for this combination: Li RJ et al. (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation. Biochem Biophys Res Commun. 2004;330(1):188-196

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.