Can You Take Dong Quai and Indole-3-Carbinol Together?

Dose or timing may matter

The short answer

Dong Quai provides estrogenic stimulation, while I3C promotes estrogen metabolism to less active metabolites. These opposing effects may reduce each other's benefits.

How to arrange timing

Choose based on hormonal goals: estrogenic support (Dong Quai) or estrogen metabolism (I3C).

Reference

Reference noted for this combination: Journal of Nutrition, 2003; 133(7): 2470S-2475S

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.