Can You Take DIM and Indole-3-Carbinol Together?

Dose or timing may matter

The short answer

I3C converts to DIM in the stomach. Taking both supplements provides redundant estrogen metabolism modulation and may lead to excessive shifts in estrogen metabolite ratios.

How to arrange timing

Consider using either DIM or I3C, not both, since I3C naturally converts to DIM.

Reference

Reference noted for this combination: Journal of Nutritional Biochemistry, 2016; 28: 70-80

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.