Can You Take D-Aspartic Acid and L-Aspartic Acid Together?

Use extra care with this pair

The short answer

D-Aspartic Acid and L-Aspartic Acid share the same amino acid transporters and metabolic pathways. D-AA stimulates testosterone and GnRH release. Combining both isomers may lead to excessive excitatory amino acid levels, potentially causing neural overexcitation.

How to arrange timing

Research suggests choosing either D-Aspartic Acid or L-Aspartic Acid rather than combining both isomers to avoid excessive aspartate levels.

Reference

Reference noted for this combination: D'Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev. 2007;53(2):215-234.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.