Can You Take Creatine and Vitamin C Together?

Dose or timing may matter

The short answer

Creatine increases renal creatinine clearance burden, while high-dose vitamin C produces oxalate that the kidneys must excrete. Together they may compound renal filtration stress.

How to arrange timing

Limit vitamin C to under 1,000 mg/day when using creatine. Drink at least 3 L of water daily to support renal clearance.

Reference

Reference noted for this combination: Poortmans JR, Francaux M. J Int Soc Sports Nutr. 2000; Traxer O et al. Kidney Int. 2003;64(3):1098-1104

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.