Can You Take Creatine and Soy Protein Isolate Together?

Dose or timing may matter

The short answer

Soy protein isolate increases urea nitrogen production, adding to creatine's creatinine clearance burden on the kidneys. Both contribute to overall renal filtration workload.

How to arrange timing

Drink 3+ L of water daily. This is a common sports nutrition combination and is generally safe with adequate hydration.

Reference

Reference noted for this combination: Martin WF et al. Nutr Metab. 2005;2:25; Kreider RB et al. J Int Soc Sports Nutr. 2017;14:18

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.