Can You Take Creatine and Ornithine HCl Together?

Dose or timing may matter

The short answer

Ornithine HCl participates in the urea cycle, increasing nitrogen metabolism demands on the kidneys. Combined with creatine's creatinine clearance requirements, total renal workload increases.

How to arrange timing

Maintain hydration at 3+ liters/day and use recommended doses. Safe for healthy kidneys but monitor if you have any renal concerns.

Reference

Reference noted for this combination: Cynober L. Ornithine alpha-ketoglutarate as a potent precursor of arginine and nitric oxide: a new job for an old friend. J Nutr. 2004;134(10 Suppl):2858S-2862S

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.