Can You Take Copper and Selenium Together?

Dose or timing may matter

The short answer

Copper and selenium have antagonistic biochemical interactions; high copper may reduce selenoprotein synthesis, while selenium can bind to copper and reduce its enzymatic availability. Both compete for thiol-group binding sites.

How to arrange timing

Take copper and selenium supplements at different times to minimize biochemical antagonism.

Reference

Reference noted for this combination: Kucharzewski M et al. Copper, zinc, and selenium in whole blood and serum. Biol Trace Elem Res. 2003;93(1-3):143-148

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.