Can You Take Copper and Menadione (Vitamin K3) Together?

May affect absorption

The short answer

Menadione (vitamin K3) is a synthetic provitamin K that undergoes redox cycling. Copper ions can catalyze menadione's redox cycling, generating reactive oxygen species. This interaction may reduce the effective bioavailability of both nutrients.

How to arrange timing

Space menadione and copper supplements at least 2 hours apart.

Reference

Reference noted for this combination: Criddle DN et al. Menadione-induced reactive oxygen species generation via redox cycling. Free Radic Biol Med. 2006;40(4):670-678

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.