Can You Take Collagen and Trypsin Together?

Dose or timing may matter

The short answer

Trypsin is a serine protease that cleaves peptide bonds in proteins. It can degrade collagen supplements in the digestive tract, converting bioactive collagen peptides into individual amino acids and reducing their specific benefits.

How to arrange timing

Take collagen supplements at least 1 hour apart from trypsin to preserve bioactive peptide structure.

Reference

Reference noted for this combination: Iwai K, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem. 2005;53(16):6531-6536.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.