Can You Take Caffeine and Resveratrol Together?

Dose or timing may matter

The short answer

Caffeine raises blood pressure while resveratrol lowers it by activating endothelial nitric oxide synthase. The opposing effects may reduce resveratrol's vascular benefits.

How to arrange timing

If using resveratrol for cardiovascular support, consider separating from caffeine.

Reference

Reference noted for this combination: Wong RHX et al. Acute resveratrol supplementation improves flow-mediated dilatation. Nutr Metab Cardiovasc Dis. 2011;21(11):851-856

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.