Can You Take Melatonin and Caffeine Together?

Dose or timing may matter

The short answer

Melatonin promotes sleep while caffeine promotes alertness. Taking them in the same time window reduces the effectiveness of both.

How to arrange timing

Schedule these in opposite parts of your day — caffeine in the morning, melatonin before bed.

Reference

Reference noted for this combination: Examine.com

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.