Can You Take Caffeine and Grape Seed Extract Together?

Dose or timing may matter

The short answer

Caffeine raises blood pressure while grape seed extract (OPCs) lowers it via vasodilation and eNOS activation. Caffeine may reduce grape seed's antihypertensive effect.

How to arrange timing

If taking grape seed extract for blood pressure support, consider separating from caffeine by a few hours.

Reference

Reference noted for this combination: Feringa HH et al. The effect of grape seed extract on cardiovascular risk markers. J Am Diet Assoc. 2011;111(8):1173-1181

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.