Can You Take Caffeine and Citrulline Silicate Together?

Dose or timing may matter

The short answer

Caffeine increases blood pressure via sympathetic stimulation while citrulline silicate promotes nitric oxide-dependent vasodilation. The opposing vascular effects may reduce the efficacy of each.

How to arrange timing

Often combined in pre-workout products. Generally safe but separate by 1–2 hours if targeting nitric oxide benefits specifically.

Reference

Reference noted for this combination: Kalman D et al. A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement. Clin Pharmacol. 2015;7:103-109

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.