Can You Take Caffeine and Citrulline Malate Together?

Dose or timing may matter

The short answer

Caffeine raises blood pressure via sympathetic activation while citrulline malate lowers it through nitric oxide-mediated vasodilation. The opposing hemodynamic effects may partially cancel each other's cardiovascular actions.

How to arrange timing

Common in pre-workout formulas and generally well-tolerated, but consider separating by 1–2 hours if targeting specific cardiovascular outcomes.

Reference

Reference noted for this combination: Wax B et al. Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise. J Strength Cond Res. 2015;29(3):786-792

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.