Can You Take Beta-Carotene and Zeaxanthin Together?

Dose or timing may matter

The short answer

High-dose beta-carotene antagonizes zeaxanthin uptake by competing for the same carotenoid-specific transport proteins, potentially reducing zeaxanthin levels in the retina.

How to arrange timing

For optimal macular support, prefer lutein/zeaxanthin supplements without high-dose beta-carotene.

Reference

Reference noted for this combination: AREDS2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration. JAMA. 2013;309(19):2005-2015

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.