Can You Take Berberine and Zinc Together?

May affect absorption

The short answer

Berberine and Zinc are both well-documented GI irritants. Simultaneous intake may cause significant nausea, cramping, and diarrhea.

How to arrange timing

Separate by at least 2 hours. Take Zinc with food.

Reference

Reference noted for this combination: Yin et al., 2012 — Berberine; NIH ODS — Zinc fact sheet

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.