Can You Take Benfotiamine and Vitamin B6 Together?

May affect absorption

The short answer

Benfotiamine is a thiamine (B1) prodrug. At high supplemental doses, B vitamins may compete for absorption via shared intestinal transporters, though benfotiamine's lipid-soluble absorption pathway partially mitigates this.

How to arrange timing

Standard doses are fine together. Only separate if taking mega-doses of individual B vitamins.

Reference

Reference noted for this combination: Lonsdale D. Evid Based Complement Alternat Med. 2006;3(1):49-59; Examine.com

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.