Can You Take Benfotiamine and Caffeine Together?

May affect absorption

The short answer

Caffeine increases thiamine excretion via diuresis and may reduce its absorption. Benfotiamine is a lipid-soluble thiamine prodrug with higher bioavailability, but concurrent caffeine may still accelerate urinary losses of its active metabolite thiamine pyrophosphate.

How to arrange timing

Space benfotiamine and caffeine at least 1-2 hours apart.

Reference

Reference noted for this combination: Lonsdale D. A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives. Evid Based Complement Alternat Med. 2006;3(1):49-59

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.