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Can You Take Ascorbyl Palmitate and Vitamin B12 Together?
May affect absorption
The short answer
Ascorbyl palmitate releases ascorbic acid during digestion, which at high doses can degrade vitamin B12 in the gastrointestinal tract by converting cobalamin to inactive analogs.
How to arrange timing
Space ascorbyl palmitate and B12 supplements at least 2 hours apart.
Reference
Reference noted for this combination: Herbert V, Jacob E. Destruction of vitamin B12 by ascorbic acid. JAMA. 1974;230(2):241-242
Important context
Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.