Can You Take Arachidonic Acid and Vitamin E Together?

May affect absorption

The short answer

Vitamin E inhibits cyclooxygenase-2 activity, which may reduce the downstream prostaglandin signaling that arachidonic acid relies on for its muscle growth effects.

How to arrange timing

Consider separating arachidonic acid and high-dose vitamin E by a few hours if using AA for exercise performance.

Reference

Reference noted for this combination: Jiang Q et al. Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001;74(6):714-722

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.