Can You Take Alpha-Lipoic Acid and Biotin Together?

Dose or timing may matter

The short answer

Alpha-lipoic acid and biotin share the same intestinal transporter (SMVT). Chronic high-dose ALA may reduce biotin status by competing for the same carrier protein at the cellular level.

How to arrange timing

If taking both long-term, consider monitoring biotin status or supplementing biotin separately.

Reference

Reference noted for this combination: Zempleni J et al. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008;3(6):715-724

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.