Can You Take Agaricus Blazei and Astragalus Together?

Dose or timing may matter

The short answer

Agaricus blazei (Himematsutake) contains beta-glucans that stimulate immune cell activity, and Astragalus is a potent immunomodulator. Combined use may cause excessive immune stimulation, which is problematic for individuals with autoimmune conditions.

How to arrange timing

Use caution when combining Agaricus blazei with Astragalus, especially if you have an autoimmune condition. Consider using them on alternating days rather than simultaneously.

Reference

Reference noted for this combination: Hetland G et al., Immunology Letters, 2011; Effects of beta-glucan-rich mushroom extracts on immune responses

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.