Can You Take Adenosylcobalamin and Cyanocobalamin Together?

May affect absorption

The short answer

Adenosylcobalamin and cyanocobalamin are both vitamin B12 forms that share the same intestinal absorption pathway via intrinsic factor and cubilin receptors. High doses of both together may compete for absorption.

How to arrange timing

Choose one B12 form or space them apart by 2 hours if using both.

Reference

Reference noted for this combination: Obeid R et al. Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency. Mol Nutr Food Res. 2015;59(7):1364-1372

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.