Can You Take 5-HTP and Melatonin Together?

Use extra care with this pair

The short answer

5-HTP is a precursor to serotonin, which is further converted to melatonin. Supplementing both may lead to excessive melatonin levels and over-sedation.

How to arrange timing

Use one or the other for sleep support, not both simultaneously.

Reference

Reference noted for this combination: Examine.com

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.