Can You Take L-Tryptophan and 5-HTP Together?

Dose or timing may matter

The short answer

Both are serotonin precursors. Combining may cause excess serotonin production and risk of serotonin syndrome.

How to arrange timing

Do not combine — use one or the other, not both.

Reference

Reference noted for this combination: Examine.com 2024

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.