Can You Take 5-HTP and Kanna Together?

Use extra care with this pair

The short answer

Kanna (Sceletium tortuosum) acts as a serotonin reuptake inhibitor (SRI). Combining with 5-HTP (a direct serotonin precursor) significantly increases the risk of serotonin syndrome.

How to arrange timing

Avoid combining Kanna with 5-HTP due to the risk of serotonin syndrome. If using both, allow at least 24 hours between doses.

Reference

Reference noted for this combination: Harvey AL, et al. J Ethnopharmacol. 2011;137(3):1124-1129; Examine.com

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.