Can You Take 5-HTP and Beta-Phenylethylamine Together?

Dose or timing may matter

The short answer

Beta-Phenylethylamine promotes dopamine and norepinephrine release, which can oppose the calming, serotonergic effects of 5-HTP. The opposing neurotransmitter actions may reduce the effectiveness of both supplements.

How to arrange timing

Consider taking 5-HTP and PEA at different times of day — PEA in the morning for energy, 5-HTP in the evening for relaxation.

Reference

Reference noted for this combination: Berry MD. Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. J Neurochem. 2004;90(2):257-271.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.