Can You Take BCAA and 5-HTP Together?

May affect absorption

The short answer

BCAAs (especially leucine) compete with 5-HTP for transport across the blood-brain barrier via the large neutral amino acid transporter (LAT1).

How to arrange timing

Space these at least 2 hours apart for optimal 5-HTP brain uptake.

Reference

Reference noted for this combination: Examine.com

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.