Does Soy foods Affect Indole-3-Carbinol?

Amount or timing may matter

The short answer

I3C promotes estrogen detoxification via CYP1A1 induction. Soy isoflavones provide competing estrogenic signals that may reduce I3C's net benefit.

How to arrange timing

Limit soy consumption when taking I3C for estrogen balance.

Reference

Reference noted for this food and supplement combination: Examine.com; Reed et al., Cancer Epidemiol Biomarkers Prev 2005

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.